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D53: landmark on baseline covariates (month-5 version as landmark_m5), NCO-1 depends on PVI-free severity, physician-cluster bootstrap script

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Co-Authored-By: Claude Opus 5.5 <[email protected]>
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chendun1995
2026-10-28 07:20:32 -04:00
co-authored by Claude Opus 5.5
parent fbc417662c
commit 5304c89316
10 changed files with 86 additions and 18 deletions
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simulations/config/experiments.yml
+3 -3
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@@ -2,11 +2,11 @@
main:
worlds: [W0, W1, W1_rho0, W2, W3, W4, W5, WR]
scenarios: ["null", harm, benefit_harm]
designs: [naive, landmark, ccw, seq]
designs: [naive, landmark, landmark_m5, ccw, seq] # landmark_m5: also adjusts for month-5 severity (supplement, D53)
variants: [V1_ignore, V3_random, V4_within] # V1 also yields V2 (cluster-robust SE)
nce: true # negative-control exposure (landmark, CCW), D32/D36
rct: [realistic, ideal]
scales:
smoke: {n_patients: 20000, reps: 1}
draft: {n_patients: 50000, reps: 100, dir: n50k}
final: {n_patients: 50000, reps: 200, dir: n50k} # extends the draft's replicates 1-100 to 200 (D51)
draft: {n_patients: 50000, reps: 100, dir: n50k_v2} # v2: D53 (landmark baseline covariates, NCO-1 severity)
final: {n_patients: 50000, reps: 200, dir: n50k_v2} # extends the draft's replicates 1-100 to 200 (D51)